Upcoming events

    • 29 Jun 2021
    • 12:00 PM - 1:00 PM (EDT)
    • Zoom; meeting link to be shared upon registration

    Of Mice and Elephants: Trade-Offs of Tumor Suppressor Duplication and Body Size Evolution in Afrotheria

    Tuesday, June 29th at 12pm EDT/18:00 CEST

    Juan Manuel Vazquez headshotJoin us for a conversation with Juan Manuel Vazquez, Postdoctoral Scholar at the University of California-Berkeley. Peto’s Paradox describes the observation that while cancer risk is correlated with body size and lifespan within species, no such correlation holds between species. This indicates that large, long-lived species have evolved enhanced cancer protection mechanisms, and that these mechanisms may be used to treat and even prevent human cancers, and extend the human healthspan. The recent expansion of body size in elephants relative to other members of their resident clade of Afrotheria led us to explore how both body size and lifespan evolved in this group. Unexpectedly, we found that tumor suppressor duplication was pervasive in Afrotherian genomes, rather than restricted to Proboscideans. Proboscideans, however, have duplicates in unique pathways that may underlie some aspects of their remarkable anti-cancer cell biology. These data suggest that duplication of tumor suppressor genes facilitated the evolution of increased body size by compensating for decreasing intrinsic cancer risk. In our talk, we will begin with a summary of these findings, then move on to a discussion of the implications of tumor suppressor duplicates in the development and fitness of various animals, and of a new paradox: how can an organism’s body size expand given enhanced genetic shackles on growth?

    Attendees are encouraged to read Vazquez and Lynch 2021, “Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk” and García-Cao et al. 2002, “‘Super p53’ mice exhibit enhanced DNA damage response, are tumor resistant and age normally.” Sign up here for the meeting link.

    • 14 Jul 2021
    • 3:00 PM (UTC-00:00)
    • 16 Jul 2021
    • 9:00 PM (UTC-00:00)
    • Online across the world

    ISEMPH 2021 will be entirely online.  See the meeting webpage for full information. 

    To register for the meeting, scroll down and click the "Register" box at the bottom left corner of this page.

    Join ISEMPH or renew your membership before continuing meeting registration to get the reduced member rate.  Members should log into their ISEMPH account before registering. If you have forgotten or never received a password, click "forgot password" on the login page. To register for the meeting without joining ISEMPH, just click the "Register" box and continue to the next page.

    • Regular registration fees began May 1
      • For all current paid-up ISEMPH members: $20
      • For non-members: $30 for students, $50 for post-doctoral scholars, and $80 for all others

      Fee categories you are not eligible for will be greyed out on the next page. If you are unable pay the registration fee, please send an email to program@isemph.org. Teachers at high schools and other non-college organizations can register at the member rate. 

    • Registered participants will receive information before the meeting about how to connect to the talks and discussion rooms from a private web page.
    • Abstract submission is separate from meeting registration. See instructions and the the link on the Abstracts webpage to submit your abstract by April 30.
    • Grand Challenges workgroups will meet twice prior to the meeting to collaborate on possible research projects that use evolutionary medicine to address major health problems. All are welcome to participate in these educational engaging exercises. Sign up here. 
    Please send questions and suggestions to program@isemph.org

    To register for the meeting, scroll down and click the "Register" box at the bottom left corner of this page

ClubEvMed is a Zoom journal club and discussion group created by Charles Nunn at the Triangle Center for Evolutionary Medicine and managed by Meredith Spence Beaulieu It was originally created to keep the evolutionary medicine community connected during a time of social distancing but its success has encouraged expanding its focus and mission. All are welcome, but most participants have a serious interest in evolutionary medicine.

If you’d like to receive emails about upcoming Club EvMed events, please subscribe to the Club EvMed email list via this form. A schedule and upcoming topics can be found here, and archived recordings of previous events can be found here.

Other sponsors of ClubEvMed include the ASU Center for Evolution and Medicine, the UCLA Center for Evolutionary Medicine, The Zurich Institute for Evolutionary Medicine and the Pittsburgh Center for Evolutionary Biology and Medicine

Steering CommitteeCharlie Nunn (TriCEM/Duke), Meredith Spence Beaulieu (TriCEM), Jay Labov (NASEM), Frank Rühli (Zurich IEM), Barbara Natterson-Horowitz (UCLA), Dan Blumstein (UCLA), Ken Buetow (ASU CEM), Charles Mitchell (TriCEM/UNC), Julie Horvath (TriCEM/NCCU), Michael Reiskind (TriCEM/NCSU), Vaughn Cooper (Pittsburgh CEBaM)


The International Society for Evolution, Medicine & Public Health is a 501(3)(c) non-profit organization. Copyright (c) 2018. Contact: manager@isemph.org
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