Upcoming events

    • 21 Oct 2021
    • 1:00 PM - 2:00 PM
    • Zoom; meeting link to be shared upon registration

    Evolutionary demography sheds light on the allelic spectrum of late-onset diseases

    Thursday, October 21st at 1pm EDT/19:00 CEST

    image of an old woman and an infantJoin us for a conversation with Samuel Pavard, Associate Professor at the National Museum of Natural History in Paris, France, and Christophe Coste, Researcher at the Norwegian University of Science and Technology. Geneticists have long considered alleles involved in post-menopause mortality to be neutral as no reproduction occurs anymore. Population genetics models have predicted that genetic drift rather than purifying selection was shaping the allelic spectrum of late-onset diseases, leading to a few common variants explaining most of the diseases’ prevalences. However, recent association studies show that most susceptibility alleles to late onset diseases have low frequencies: a characteristic of alleles under negative selection. We show that susceptibility alleles to late onset diseases are under purifying selection for most known age-at-onset distributions of late-onset genetic diseases. We conclude that neutrality is probably the exception among alleles that have a deleterious effect in old age and that accounting for sociocultural factors is required to understand the full extent of the force of selection shaping senescence in humans.

    Attendees are encouraged to read Pavard and Coste 2021, “Evolutionary demographic models reveal the strength of purifying selection on susceptibility alleles to late-onset diseases.” Sign up here for the meeting link.

ClubEvMed is a Zoom journal club and discussion group created by Charles Nunn at the Triangle Center for Evolutionary Medicine and managed by Meredith Spence Beaulieu It was originally created to keep the evolutionary medicine community connected during a time of social distancing but its success has encouraged expanding its focus and mission. All are welcome, but most participants have a serious interest in evolutionary medicine.

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Other sponsors of ClubEvMed include the ASU Center for Evolution and Medicine, the UCLA Center for Evolutionary Medicine, The Zurich Institute for Evolutionary Medicine and the Pittsburgh Center for Evolutionary Biology and Medicine


Steering CommitteeCharlie Nunn (TriCEM/Duke), Meredith Spence Beaulieu (TriCEM), Jay Labov (NASEM), Frank Rühli (Zurich IEM), Barbara Natterson-Horowitz (UCLA), Dan Blumstein (UCLA), Ken Buetow (ASU CEM), Charles Mitchell (TriCEM/UNC), Julie Horvath (TriCEM/NCCU), Michael Reiskind (TriCEM/NCSU), Vaughn Cooper (Pittsburgh CEBaM)


 

The International Society for Evolution, Medicine & Public Health is a 501(3)(c) non-profit organization. Copyright (c) 2018. Contact: manager@isemph.org
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