Upcoming events

    • 29 Jun 2021
    • 12:00 PM - 1:00 PM (EDT)
    • Zoom; meeting link to be shared upon registration

    Of Mice and Elephants: Trade-Offs of Tumor Suppressor Duplication and Body Size Evolution in Afrotheria

    Tuesday, June 29th at 12pm EDT/18:00 CEST

    Juan Manuel Vazquez headshotJoin us for a conversation with Juan Manuel Vazquez, Postdoctoral Scholar at the University of California-Berkeley. Peto’s Paradox describes the observation that while cancer risk is correlated with body size and lifespan within species, no such correlation holds between species. This indicates that large, long-lived species have evolved enhanced cancer protection mechanisms, and that these mechanisms may be used to treat and even prevent human cancers, and extend the human healthspan. The recent expansion of body size in elephants relative to other members of their resident clade of Afrotheria led us to explore how both body size and lifespan evolved in this group. Unexpectedly, we found that tumor suppressor duplication was pervasive in Afrotherian genomes, rather than restricted to Proboscideans. Proboscideans, however, have duplicates in unique pathways that may underlie some aspects of their remarkable anti-cancer cell biology. These data suggest that duplication of tumor suppressor genes facilitated the evolution of increased body size by compensating for decreasing intrinsic cancer risk. In our talk, we will begin with a summary of these findings, then move on to a discussion of the implications of tumor suppressor duplicates in the development and fitness of various animals, and of a new paradox: how can an organism’s body size expand given enhanced genetic shackles on growth?

    Attendees are encouraged to read Vazquez and Lynch 2021, “Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk” and García-Cao et al. 2002, “‘Super p53’ mice exhibit enhanced DNA damage response, are tumor resistant and age normally.” Sign up here for the meeting link.

    • 14 Jul 2021
    • 3:00 PM (UTC-00:00)
    • 16 Jul 2021
    • 9:00 PM (UTC-00:00)
    • Online across the world
    Register

    ISEMPH 2021 will be entirely online.  See the meeting webpage for full information. 

    To register for the meeting, scroll down and click the "Register" box at the bottom left corner of this page.

    Join ISEMPH or renew your membership before continuing meeting registration to get the reduced member rate.  Members should log into their ISEMPH account before registering. If you have forgotten or never received a password, click "forgot password" on the login page. To register for the meeting without joining ISEMPH, just click the "Register" box and continue to the next page.

    • Regular registration fees began May 1
      • For all current paid-up ISEMPH members: $20
      • For non-members: $30 for students, $50 for post-doctoral scholars, and $80 for all others

      Fee categories you are not eligible for will be greyed out on the next page. If you are unable pay the registration fee, please send an email to program@isemph.org. Teachers at high schools and other non-college organizations can register at the member rate. 


    • Registered participants will receive information before the meeting about how to connect to the talks and discussion rooms from a private web page.
    • Abstract submission is separate from meeting registration. See instructions and the the link on the Abstracts webpage to submit your abstract by April 30.
    • Grand Challenges workgroups will meet twice prior to the meeting to collaborate on possible research projects that use evolutionary medicine to address major health problems. All are welcome to participate in these educational engaging exercises. Sign up here. 
    Please send questions and suggestions to program@isemph.org

    To register for the meeting, scroll down and click the "Register" box at the bottom left corner of this page

Past events

21 Jun 2021 Club EvMed: Evolution management from a game-theory perspective
11 Jun 2021 Club EvMed: Why is human childbirth so difficult?
17 May 2021 Club EvMed: Divergent evolutionary roots for posttraumatic stress disorder symptoms
10 May 2021 Club EvMed: The COVID-19 Pandemic and Human Nature
29 Apr 2021 Club EvMed: Postdoc Spotlight
21 Apr 2021 Club EvMed: Die young, live fast
5 Apr 2021 Club EvMed: Causes and consequences of fear of childbirth
1 Apr 2021 Club EvMed: The WEIRDest People in the World
25 Mar 2021 Club EvMed: Harnessing the social lives of microbes to improve human health
9 Mar 2021 Club EvMed: 7 Metabolic Myths
23 Feb 2021 Club EvMed: Does evolutionary biology have anything to say about how we should use antibiotics?
17 Feb 2021 Club EvMed: HIV and male sexual behavior: a hypothesis and its history
11 Feb 2021 Club EvMed: How vaccines train the immune system in ways no one expected
28 Jan 2021 Club EvMed: Successful Aging in the Forest
22 Jan 2021 Club EvMed: Wealth, inequality, and health in a small-scale subsistence society
11 Jan 2021 Club EvMed: Integrating evolutionary dynamics into clinical cancer treatment
1 Dec 2020 Club EvMed: Age-dependence in evolutionary mismatch with Michael R. Rose and Grant Rutledge
17 Nov 2020 Club EvMed: Social immunity with Sylvia Cremer, Nathalie Stroeymeyt, and Chris Pull
12 Nov 2020 Club EvMed: The Nature of Fear with Daniel Blumstein
4 Nov 2020 Club EvMed: Postdoc Spotlight with Caroline Amoroso, Amrita Bhattacharya, and Angela Garcia
27 Oct 2020 Club EvMed: Pathogen selection for HLA gene diversity with Tobias Lenz
19 Oct 2020 Club EvMed: evolutionary understanding of aging and cancer with James DeGregori
13 Oct 2020 Club EvMed: Survival of the Friendliest with Brian Hare
6 Oct 2020 Club EvMed: SARS-CoV-2 susceptibility in 400 species with Elinor Karlsson
1 Oct 2020 Club EvMed: Race and evolutionary medicine with Joseph L. Graves Jr.
24 Sep 2020 Club EvMed: Student Spotlight with Lafi Aldakak, Chenlu Di, and Iman Hamid
17 Sep 2020 Club EvMed: Physical inactivity with Daniel Lieberman
10 Sep 2020 Club EvMed: Human birth timing with Abbe Labella, Abin Abraham, Lou Muglia, Antonis Rokas, and Tony Capra
3 Sep 2020 Club EvMed: Cancer and life history traits with Amy Boddy
27 Aug 2020 Club EvMed: Racial differences in immune respone to Helicobacter pylori with Meira Epplein and Julia Butt
20 Aug 2020 Club EvMed: The new tangled bank of disease with Brandon Ogbunu
20 Jul 2020 Club EvMed: High-altitude hypoxia with Cynthia Beall
15 Jul 2020 Cancelled: 2020 ISEMPH Pre-Meeting Workshop
15 Jul 2020 Cancelled: ISEMPH 2020 in Athens, Georgia
14 Jul 2020 Club EvMed: Tracking pathogens through time with Verena Schuenemann
6 Jul 2020 Club EvMed: Evolution of skin color with Nina Jablonski
30 Jun 2020 Club EvMed: The nature of adolescence with B. N. Horowitz
23 Jun 2020 Club EvMed: Batural Selection with Bernard Crespi
15 Jun 2020 Club EvMed: Social determinants of health with Jenny Tung, Noah Snyder-Mackler, and Dan Belsky
11 Jun 2020 Club EvMed: Tacit creationism in emotions research with Randolph Nesse
3 Jun 2020 Club EvMed: The role of chance in evolution with Sean B. Carroll
26 May 2020 Club EvMed: The evolution of cheating cells in cancer with Athena Aktipis
18 May 2020 ClubEvMed: Evolution and Avoiding Catastrophic Risks with Daniel Blumstein and Terence Taylor
15 May 2020 ClubEvMed: Cytokine Storm with Joe Alcock
13 Aug 2019 ISEMPH 2019 in Zurich
1 Aug 2018 ISEMPH 4th Annual Meeting

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