Upcoming events

    • 10 Feb 2022
    • 12:00 PM - 1:00 PM
    • Zoom; meeting link to be shared upon registration


    Candidate gene studies have taught us little about trait genetics but a lot about the fallibility of the scientific process

    Thursday, February 10th at 12pm EST/18:00 CET

    picture of Matt KellerJoin us for a conversation with Matt Keller, Associate Professor in the Dept. of Psychology & Neuroscience at the University of Colorado, Boulder. The candidate gene (CG) approach has been used for 30 years to investigate the influence of specific polymorphisms in genes thought a-priori to be related to complex traits. Thousands of such studies have been and continue to be conducted, most reporting significant associations. In the last 15 years, a much different approach, the genome-wide association study (GWAS), has been used to investigate nearly all common genetic polymorphisms across the genome at once. Using sample sizes orders of magnitude larger than typical CG studies, GWASs have made tens of thousands of reliable discoveries, but the effect sizes are typically much smaller than those detected in CG studies, and specific CG hypotheses have failed to replicate when directly interrogated in GWAS data. What might explain these apparent contradictions? It is possible that CG studies measure traits with higher precision or that they investigate less complex “endophenotypes,” but neither explanation holds up under scrutiny. Rather, CG studies suffer from many factors—publication bias, inconsistent methodological practices, low priors, and low power—that increase the false positive rate in any field. We argue that the many positive findings using the GC approach are largely false positives and are a humbling reminder of the fallibility of the scientific process as currently practiced.

    Attendees are encouraged to read Duncan and Keller 2011, “A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry” and Border et al. 2019, “No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples.” Attendees may also be interested in a response to critique (Border et al. 2019) and a popular media article about this research (Yong). Sign up here for the meeting link.

Past events

18 Jan 2022 Club EvMed: A Natural History of the Future
11 Jan 2022 Club EvMed: Control system failures and evolutionary medicine
14 Dec 2021 Club EvMed: Genetic adaptation to zoonotic viruses: how did chimpanzees adapt to SIV/HIV infections?
2 Dec 2021 Club EvMed: The genetic history of the plague: what we learn from ancient pandemics
18 Nov 2021 Club EvMed: Deciphering the persistence of antimicrobial resistance in the absence of antimicrobial pressure using a One Health approach
4 Nov 2021 Club EvMed: Can evolution-thinking bring phage therapy closer to standard-of-care?
21 Oct 2021 Club EvMed: Evolutionary demography sheds light on the allelic spectrum of late-onset diseases
14 Oct 2021 Club EvMed: How evolutionary behavioural sciences can help us understand behaviour in a pandemic
21 Sep 2021 Club EvMed: The durability of immunity against reinfection by SARS-CoV-2
9 Sep 2021 Club EvMed: Alzheimer's Disease: a case of evolutionary mismatch?
24 Aug 2021 Club EvMed: SARS-CoV-2 transmission bottlenecks and why we care
21 Jul 2021 Club EvMed: Understanding evolutionary mismatch at the genomic level
14 Jul 2021 ISEMPH 2021
29 Jun 2021 Club EvMed: Of Mice and Elephants
21 Jun 2021 Club EvMed: Evolution management from a game-theory perspective
11 Jun 2021 Club EvMed: Why is human childbirth so difficult?
17 May 2021 Club EvMed: Divergent evolutionary roots for posttraumatic stress disorder symptoms
10 May 2021 Club EvMed: The COVID-19 Pandemic and Human Nature
29 Apr 2021 Club EvMed: Postdoc Spotlight
21 Apr 2021 Club EvMed: Die young, live fast
5 Apr 2021 Club EvMed: Causes and consequences of fear of childbirth
1 Apr 2021 Club EvMed: The WEIRDest People in the World
25 Mar 2021 Club EvMed: Harnessing the social lives of microbes to improve human health
9 Mar 2021 Club EvMed: 7 Metabolic Myths
23 Feb 2021 Club EvMed: Does evolutionary biology have anything to say about how we should use antibiotics?
17 Feb 2021 Club EvMed: HIV and male sexual behavior: a hypothesis and its history
11 Feb 2021 Club EvMed: How vaccines train the immune system in ways no one expected
28 Jan 2021 Club EvMed: Successful Aging in the Forest
22 Jan 2021 Club EvMed: Wealth, inequality, and health in a small-scale subsistence society
11 Jan 2021 Club EvMed: Integrating evolutionary dynamics into clinical cancer treatment
1 Dec 2020 Club EvMed: Age-dependence in evolutionary mismatch with Michael R. Rose and Grant Rutledge
17 Nov 2020 Club EvMed: Social immunity with Sylvia Cremer, Nathalie Stroeymeyt, and Chris Pull
12 Nov 2020 Club EvMed: The Nature of Fear with Daniel Blumstein
4 Nov 2020 Club EvMed: Postdoc Spotlight with Caroline Amoroso, Amrita Bhattacharya, and Angela Garcia
27 Oct 2020 Club EvMed: Pathogen selection for HLA gene diversity with Tobias Lenz
19 Oct 2020 Club EvMed: evolutionary understanding of aging and cancer with James DeGregori
13 Oct 2020 Club EvMed: Survival of the Friendliest with Brian Hare
6 Oct 2020 Club EvMed: SARS-CoV-2 susceptibility in 400 species with Elinor Karlsson
1 Oct 2020 Club EvMed: Race and evolutionary medicine with Joseph L. Graves Jr.
24 Sep 2020 Club EvMed: Student Spotlight with Lafi Aldakak, Chenlu Di, and Iman Hamid
17 Sep 2020 Club EvMed: Physical inactivity with Daniel Lieberman
10 Sep 2020 Club EvMed: Human birth timing with Abbe Labella, Abin Abraham, Lou Muglia, Antonis Rokas, and Tony Capra
3 Sep 2020 Club EvMed: Cancer and life history traits with Amy Boddy
27 Aug 2020 Club EvMed: Racial differences in immune respone to Helicobacter pylori with Meira Epplein and Julia Butt
20 Aug 2020 Club EvMed: The new tangled bank of disease with Brandon Ogbunu
20 Jul 2020 Club EvMed: High-altitude hypoxia with Cynthia Beall
15 Jul 2020 Cancelled: 2020 ISEMPH Pre-Meeting Workshop
15 Jul 2020 Cancelled: ISEMPH 2020 in Athens, Georgia
14 Jul 2020 Club EvMed: Tracking pathogens through time with Verena Schuenemann
6 Jul 2020 Club EvMed: Evolution of skin color with Nina Jablonski
30 Jun 2020 Club EvMed: The nature of adolescence with B. N. Horowitz
23 Jun 2020 Club EvMed: Batural Selection with Bernard Crespi
15 Jun 2020 Club EvMed: Social determinants of health with Jenny Tung, Noah Snyder-Mackler, and Dan Belsky
11 Jun 2020 Club EvMed: Tacit creationism in emotions research with Randolph Nesse
3 Jun 2020 Club EvMed: The role of chance in evolution with Sean B. Carroll
26 May 2020 Club EvMed: The evolution of cheating cells in cancer with Athena Aktipis
18 May 2020 ClubEvMed: Evolution and Avoiding Catastrophic Risks with Daniel Blumstein and Terence Taylor
15 May 2020 ClubEvMed: Cytokine Storm with Joe Alcock
13 Aug 2019 ISEMPH 2019 in Zurich
1 Aug 2018 ISEMPH 4th Annual Meeting

The International Society for Evolution, Medicine & Public Health is a 501(3)(c) non-profit organization. Copyright (c) 2018. Contact: manager@isemph.org
Powered by Wild Apricot Membership Software