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Club EvMed: Age-dependence in evolutionary mismatch with Michael R. Rose and Grant Rutledge

  • 1 Dec 2020
  • 2:00 PM - 3:00 PM
  • Zoom; meeting link to be shared upon registration

Age-dependence in evolutionary mismatch

Tuesday, December 1st at 2pm EST

Join us for a conversation with Michael R. Rose, Distinguished Professor of Ecology and Evolutionary Biology at the University of California, Irvine and Director of the Network for Experimental Research on Evolution, and Grant Rutledge, Research Associate in the Neuroscience and Aging Lab at Tufts University. Human health depends on age and evolutionary history. Firstly, adaptation is age-specific, with Hamilton’s forces of natural selection leading to much greater adaptation at earlier ages than later ages. This of course is how evolutionary biologists explain the existence of aging in the first place. Secondly, when environmental conditions change, it takes surprisingly few generations for populations to adapt to such new conditions, at least at ages when natural selection is intense. Thirdly, at later ages, when the forces of natural selection are weak, natural selection will often fail to produce adaptation to a selective environment that is not evolutionarily ancient. All three of these themes will be illustrated using both explicit mathematical theory and findings from experimental evolution. At the end of the presentation, we will apply these general scientific insights to the case of human evolutionary history, human aging, and optimal human diets.

Attendees are encouraged to read Rutledge et al. 2020, “Hamiltonian patterns of age-dependent adaptation to novel environments” and Rutledge et al. 2020, “Diet and botanical supplementation: Combination therapy for healthspan improvement?” Sign up here for the meeting link.

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